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IV-361 - CAS# 2055741-39-2 Catalog No.:M16736-C In the cathepsin L inhibition

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Description

In the cathepsin L inhibition assay

Takayasu T

Zoledronic acid inhibits osteoclast maturation indirectly by increasing OPG protein secretion and decreasing transmembrane RANKL expression in human osteoblasts

2ClH/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20

All cells die at concentrations above 10 μmol/L for DC661 in contrast to Lys05 and HCQ

IV-361 - CAS# 2055741-39-2 Catalog No.:M16736-C In the cathepsin L inhibitionIV 361 is an orally active and selective CDK7 inhibitor (Ki50 nM). IV 361 has anti cancer activity (US20190256531A1). Product information CAS Number: 2055741 39 2 Molecular Weight: 457. 62 Formula: C23H32FN5O2Si Chemical Name: N (5 fluoro 2 methylphenyl) 6, 6 dimethyl 3 [1 (trimethylsilyl)cyclobutaneamido] 1H, 4H, 5H, 6H pyrrolo[3, 4 c]pyrazole 5 carboxamide Smiles: CC1(C)C2NN=C(NC(=O)C3(CCC3)[Si](C)(C)C)C=2CN1C(=O)NC1=CC(F)=CC=C1C InChiKey:

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